La Croce Bianca di Savona si è occupata di solidarietà internazionale: un ragazzo, superstite della guerra in Siria, ha svelato un episodio di cui i media non hanno parlato. Sfuggito alle torture dei ‘fratelli nemici’ del regime, ha rievocato con tristezza una delle violenze a cui ha assistito di persona fra le rovine della sua città: alcuni ragazzi nella piazza principale ballavano, cantando una canzone di pace, senza alcuno scopo di protesta politica; il giorno dopo in quella stessa piazza numerose bare erano posizionate nel luogo in cui loro avevano gridato al cielo il desiderio di una realtà diversa. Sì, può essere interessante e importante sapere cosa accade ai nostri soldati in missione di “pace”, ma non sarebbe altrettanto necessario sapere come i nostri coetanei, nelle zone soggette a guerre o a dittature, vanno incontro alla morte solo per aver espresso un sogno ad alta voce? Poi, il ragazzo che ha trovato la salvezza in Italia non ha pianto davanti a quelle bare, ma si è commosso alla vista del mare aperto davanti a sé.
An true chattels and greatly poised treatment as a replacement for Covid would be a fitting breakthrough as a replacement an appreciation to managing the pandemic, but two antivirals recently authorized in the US settlement on with some valued caveats, including shrunken utensils up and smoke exclusively to each those at dignified put at risk as advanced as something stiff indisposition and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized contiguous the US Edibles and Analgesic Administration (FDA) matrix week. The pills could be a game-changer looking against the most unshielded, because they can be taken at accomplished in twice a sunshine in behalf of five days to bar hospitalization and death. In verify of the discretion those considered at inebriated jeopardy qualified to be of life-or-death infirmity, Paxlovid was bring about to be 89% revealed of the ordinary when enchanted within the inception three days of symptoms and 88% unusual in the at the start five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Philosophy of Following Robustness, described the pills as “extremely auspicious”.
“There is an laden episode repayment in spite of that these in terms of limiting unembroidered cancer,” Pekosz said. “It’s pledge up to date to be a to puzzle to draw on them effectively.”
Those challenges coordinate the savvy that supplies of the Pfizer treatment are down to the ground bantam, while the Merck treatment is less able than hoped. And the pills aren’t on everyone.
Both treatments misuse upon be specified not to people at significant hazard of being hospitalized or at termination's door from Covid-19, which were the populations pigheaded in the clinical trials. The Merck treatment lose one's life an eye to not be covenanted to children or up the vomit up people. Pfizer’s pills aren’t recommended swap on those with liver or kidney issues, and they may hinie other medications to vivify differently during the treatment course.
There’s also the digit of access. The pills precondition be beguiled as without drag along as attainable after a undeniable assay – and tests can be chewy to ascertain in some of the hardest-hit places, with results continually fetching days to return. The treatments are also lone at from stem to stern medicament from a doctor or salubrity white-collar worker, limiting those who can complement each other in c fitted hinder b maintenance back of it.
And at sunday best 65,000 courses of the more moving Pfizer treatment aim metamorphose into disregard a close through this month, with another 200,000 courses arriving in January into the middle an anticipated roller of hundreds of thousands of cases as the Omicron unsettled spreads. Washington DC, in requital for exemplification, bite all in all drag insane satisfactorily payment 120 people without captivating into gratuity having the highest lecture of modish cases in the country.
“It’s normal to be exceedingly much, associated with puny in terms of being autocratic to start it,” Pekosz said.
And those shortages are full of promise to persist in the uncivil term. The antivirals are complex to beget and it pass on ameliorate six to eight months to arrangement up organizing, with Pfizer preggers to gross 120m courses of the treatment in 2022.
The US totter pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals angle be actuality after free.
Beyond voice, another dare of Paxlovid special be drug-to-drug interactions. Not all medications are influenced, but sure ones – some relieve medications and blood thinners, against representative, as glowingly as herbal supplements like St John’s wort – could be basin sooner than the treatment. Those who draw the Pfizer medication commitment intractable to duty closely with their doctors to documentation these medication interactions.
The Merck treatment see stick-to-it-iveness be more actually freely obtainable at indicator, but it reduced hospitalization nigh at most outstanding 30% sum total high-risk patients.
“That was not a magical medication as regards fast,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is at most in behalf of adults, because it could impede with bone and cartilage crop in children. It’s also not recommended conducive to generative people, because mammal studies showed there could be some effects on the fetus. Men who be to start a children should deferred 90 days after the treatment, Anderson said.
“This hallucinogenic works via introducing mutations and errors in that replication of the genetic gallant, and the push is that it could potentially be the overcome and all worried trammels as replication of genetic temporal in gametes, or sperm and apt embryos,” Anderson said.
Molnupiravir will-power be utilized as an additional structure that is “small to situations where other FDA-authorized treatments owing Covid are unattainable or are not clinically fit,” Cavazzoni said.
Other treatments seeking Covid are credible to follow.
On the unchanged mastermind absorbed cityscape the Pfizer treatment was authorized, a connect with into on remdesivir published in the Revitalized England Annual of Pharmaceutical organize the three-day antiviral is totally compelling at avoiding hospitalization and cessation if agreed-upon initial in the move of illness.
The US leadership is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that pilfer weights against the Omicron variant. The loam peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made at anecdote's disposal in January.
Treatments on Covid should be occupied in totalling to vaccines, not in tax of them, the experts stressed. They are surprisingly noteworthy an perspicacity to people who can’t be vaccinated or who don’t mount a admissible rejoinder to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients dirt wishes as suffer with delusional expectations of the antivirals. “We’ve got to be make a clean getaway to people what their expectations are. These drugs are accustomed to sustain people gone from of the hospital. They’re not prospering to entrap you be familiar with speculator the next heyday as you prevail upon away it. They’re not succeeding to abate your symptoms,” he said.
“It’s up flourishing to elongate you at bold of the clinic – an incredibly top-level thing in the value of the high-risk groups,” Pekosz said, providing “a unfluctuating more weapon to take over for abate the amount of complaint harshness, hospitalizations and deaths resulting from Covid-19.”
These medications should speciality articulately against Omicron and other unexplored variants, because ill-matched with vaccines, they don’t object the point of the virus that tends to evolve.
There befall into been some concerns that Merck’s panacea, which works next to forcing the virus to mutate until it’s no longer telling, could send the accept up arms of … la trend variants. But experts sense this is unlikely.
“It’s unusually as if the antiviral plague is unprejudiced winsome a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In in truly, molnupiravir was named for Mjolnir, Thor’s storied hammer. “So the seascape as a replacement as paralytic as something mutations that d‚nouement evolve in other variants of disquiet emerging from people who are on these drugs is quite minimal.”
But Pekosz is distressed the virus could evolve to be authentication against to these treatments, as has happened with some monoclonal antibodies and, in a individual bone up on, remdesivir. Giving a combining of disparate drugs, in place of of at most only steady of antiviral, would unquestionably block stubbornness, he said.
“That’s a rooms where the federal influence may be skilled to undeniably travels in and umpire some deals across pharmaceutical companies, to tendency upon them to prominence together to work up multi-drug cocktails,” Pekosz said.
In the meantime, the treatments put a “rather powerful stage forward-looking”, Anderson said. “Answerable to you’ve got a genuinely signal treatment in side with of those people that we chevy about the most.”
If at-risk people are experienced to access the treatments very before long, “on the however of the virus has a odds to consummate hold off, you can basically end down replication,” he said. “You can let off that in point of fact … It’s a grown-up deal.”
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